Prediction of immunoglobulins from patterns of cellulose acetate electrophoresis.

The concentrations of serum immunoglobulins (Ig) C, A, and M were correlated with specific features in the $y region of densitometer patterns of serum protein electrophoresis on cellulose acetate membranes; visual analysis of densitometer patterns permitted semiquantitative prediction of values for lgC and lgA. Important immunoglobulin abnormalities, particularly elevations of IgA, were seen in some cases even when normal values were obtained from analyses of electrophoresis by usual densitometer integrator technics; many such instances were detectable by inspection of the densitometer tracing.